Its most likely not a blocked port. I am guessing its an anti-virus or firewall issue getting access to this site. Try disabling those first.
I'd need more info. Are you using wireless in both instances? If you're using wired for your home isp and wireless for the hotspot it could be what Junkee suggests. However if you're using wireless in both instances and it works with the hotspot and not your isp, it could be an issue on their end.
If you have an isp that doesn't allow you access to the router to forward ports, what you'll probably want to do is call them up and tell them you have an XBox or a PS and ask if they can open up ports on your router so you can have better online gaming. Those ports tend to be the same as ones used by websites and such. That would eliminate port issue.
Of course what I should be asking first and foremost is what exactly do you mean when you say you can't access this site? Are you getting some kind of browser error? If so, what browser(s) are you using?
A real longshot as well is it could be that the public IP your ISP is giving you could be on a blacklist with some sites.
Without more info I can't do more specific troubleshooting.