Pretty good matchup.
Kelly Hu - 5' 5", 112-115, 34-24-34, 45 years old.
Kaley Cuoco - 5' 7", 125-130, 34-24-36, 27 years old.
[Stats for both ladies vary from one source to another. I actually think Kelly is 5' 4 1/2", but I've listed the most commonly cited stats for each above, and the most common ranges for their weight.]
Kelly does have a legitimate background in Karate. Kaley was an accomplished athlete before acting full-time, and kickboxes regularly.
A case could be made for this one going either way. Looking at the stats, I think I'd give Kaley a slight overall advantage. She's two inches taller and about a dozen pounds heavier, and is eighteen years younger. 5-7 years ago I'd probably have gone the other way, but at this point Kaley gets my vote.
-JM